Introduction

A diabetic foot ulcer is a complication of diabetes mellitus, which is an endocrine metabolic disorder characterized by insulin deficiency in type I diabetes mellitus and insulin dysfunction in type II diabetes mellitus. The development of diabetic ulcers is triggered by minor trauma to the skin. The major risk factors for the development of diabetic ulcers include vascular insufficiency, peripheral sensory and/or motor neuropathy, hyperglycemia, peripheral autonomic neuropathy, abnormal anatomical arrangement, and neuro-osteoarthropathy deformities.

The three forms of diabetic ulcers are ischemic, neuropathic, and neuroischemic diabetic ulcers. The stages of diabetic ulcer comprise the absence of risk factors, the occurrence of risk factors, ulceration, cellulitis, necrosis, and irreversible damage.

The progression and outcomes of diabetic ulcers are determined by the control of diabetes, awareness, and education of the patients, appropriate wound care, and healthy lifestyle practices. Diabetic ulcers shall be treated promptly and properly since delayed or total lack of management of these wounds can manifest as limb ischemia, abscess formation, gangrene, cellulitis, osteomyelitis, and even amputation of the affected region. [1]

What is worse than losing a whole limb to a metabolic condition that one can control and prevent. Read the following sections to know how one can treat diabetic ulcers and save his or her limb.

CleaDerma DCB Ointment for the Treatment of Diabetic Ulcers

CleaDerma DCB Ointment is an effective, affordable, and non-invasive pharmaceutical formulation, developed by Pharma Naturalis, for the treatment of several skin conditions that include venous ulcers, pressure ulcers, xerosis, and diabetic ulcers. The ointment works in the environment of diabetic ulcers. The ingredients in the ointment enrich the skin with all the necessary components to heal, revive, and rejuvenate.

The biologically active ingredients of the CleaDerma DCB ointment include Dead Sea salt, aloe vera, sage, calendula oil, and avocado oil. These ingredients contain all the necessary molecules and nutrients to restore the normal structure and function of the skin. [2]

How can an ointment save your limb from being amputated? 

1. Reduced blood supply may further deteriorate the condition of ulcers and exacerbate damage to the tissues. This may also deprive the tissues of nutrients, which are otherwise important for the healing of ulcers. The topical application of aloe vera gel reduces the surface of ulcers and promotes the formation of blood vessels, called angiogenesis, in diabetic ulcers. Aloe vera facilitates homing of the endothelial progenitor cells, increases the concentration of vascular endothelial growth factor, and reduces the concentration of circulating endothelial cells. Aloe vera provides nutrients necessary for wound healing, reduces inflammation, and accelerates the completion of the wound healing process. [3]
2. Inflammation at the site of ulcers elicits pain, prolongs wound healing, and causes damage to the tissues. Calendula officinalis oil is an effective natural constituent of the ointment for the treatment and management of diabetic ulcers. The anti-inflammatory properties of the calendula oil help relieve pain and accelerate wound healing. Flavonoids in the oil suppress microbial growth and the onset of infections. The oil also stimulates the epithelization of wounds and the formation of new blood vessels. [4, 5]
3. The underlying tissues are exposed to the external environment and vulnerable to bacterial, viral, and fungal infections of the ulcers, making the ulcers look even worse. Reactive oxygen species released during inflammation of the tissues, contribute to further damage of the tissues, worsening the ulcers. The therapeutic effects of sage (Salvia officinalis) in the treatment and management of diabetic ulcers are attributed to its anti-inflammatory, antimicrobial, and antioxidant properties. [6]
4. The skin at the site of diabetic ulcers becomes weak and damaged. Avocado oil, which originated from avocado (Persea americana), has a higher concentration of linolenic acid and linoleic acid, which are polyunsaturated fatty acids, and monounsaturated fatty acids including oleic acid. The oil also contains vitamins (A, E, D, and C), beta-carotene, minerals, lecithin, and beta-sitosterol. Avocado oil alleviates inflammation, reduces inflammatory cells, and promotes the maturation of scar tissue. Avocado oil is associated with remodeling of the wound and an increase in tensile strength of the wound. [7]
5. The Dead Sea is a rich source of magnesium salts and other minerals, which play an important role in the treatment and management of diabetic ulcers. These salts accelerate the healing and contraction of the cutaneous wounds as well as enhance the epithelization, granulation, collagen synthesis, collagen deposition, and formation of blood vessels at the site of the wound. The Dead Sea salts have anti-inflammatory, antioxidant, and antimicrobial activities, making these salts an effective component of the CleaDerma DCB ointment.

Luckily, one can find all the above ingredients in the CleaDerma DCB Ointment. These ingredients work together to eliminate the free radicals and pathogens to alleviate inflammation and promote the healing of diabetic ulcers.

Potential Adverse Effects of CleaDerma DCB Ointment

The CleaDerma DCB Ointment is safe for topical use by adults and children older than 10 years of age. Before application, one must check for ingredients, which may be associated with potential allergies or hypersensitivity reactions. One shall do a patch test before applying the ointment to the skin area with a diabetic ulcer.

Conclusion

CleaDerma DCB Ointment is an affordable, natural, and effective topical formulation for the treatment and management of diabetic ulcers, xerosis, pressure ulcers, and venous ulcers. The topical application of the ointment nourished the skin with important constituents to rejuvenate, heal, and revive itself. The active ingredients of the CleaDerma DCB Ointment include avocado oil, Dead Sea salts, calendula oil, sage, and aloe vera. These ingredients have wound healing, wound contraction, ulcer surface reduction, angiogenic, antimicrobial, anti-inflammatory, and antioxidant properties. The combined action of these ingredients makes this ointment a great therapeutic formulation for the treatment and management of diabetic ulcers as well as for restoring the normal properties of the skin. 

References

1. 1. https://www.ncbi.nlm.nih.gov/books/NBK499887/
   2. https://dcb-care.com/case-study/
   3. https://inabj.org/index.php/ibj/article/view/152/181
   4. https://www.scielo.br/j/reeusp/a/ppnqYts7J7BW9JPPZD56xyf/?lang=en
   5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270572/
   6. https://www.sciencedirect.com/science/article/pii/S2225411017300056https://www.hindawi.com/journals/ecam/2013/472382/
   7. https://scialert.net/fulltext/?doi=pjbs.2012.306.31