Introduction

Venous ulcers are described as open lesions that arise on the lower extremities. Approximately 1-3% of the United States population suffers from venous ulcers. Venous ulcers occur in individuals who are suffering from venous hypertension. This condition may result from obstruction of the veins or incompetence of the valves leading to venous reflux. Important risk factors are positive family history of venous reflux or valve incompetence, a history of thrombus or embolus formation, 55 years of age or older, musculoskeletal disorder of the lower extremity, physical inactivity, multiple pregnancies, and severe lipo-dermatosclerosis.

While some lesions in venous ulcers heal, healing in other cases may be hindered by poor prognostic factors such as duration longer than three months, length of ulcers more than 10 cm, older age, increased body mass index, and pre-existing arterial disease of the lower limb. [1]

The standard therapeutic measures for treating and managing venous ulcers include compression therapy, which reduces leg edema, and direct management of the wound. In addition to non-invasive procedures, invasive interventions are required to remove incompetent veins. Techniques used for removing such veins include open vascular surgery, endovenous procedures, sclerotherapy, and radiofrequency. [2]

Venous ulcers can deteriorate the quality of life of an individual. From the non-satisfactory cosmetic appearance of the skin to the lousy odor and damaged tissues, venous ulcers can take a toll on one’s life. Although the treatments mentioned above are efficacious, they are invasive and can be expensive. Not everyone is ready to be under the knife.

Even if you are already an expert in caring for your loved one and have tried everything, it is essential to know that it does not always work! Sometimes more than one treatment is needed, or a specific treatment that helps one does not necessarily help another. Steroids and chemicals can speed up skin renewal, but does the skin return to being as strong and supple as it was? No! Therefore, the likelihood that a chronic wound will reappear is higher! That’s why we recommend the CleaDerma DCB ointment made from 100% natural active ingredients, which will return the skin to its natural and strong elasticized state so that the wound will be more challenging to develop. In addition, constant use of the ointment even after the wound is closed maintains the skin’s health and reduces the risk of developing a chronic wound.

CleaDerma DCB Ointment is a cost-efficient, non-invasive, and effective topical formulation developed by Pharma Naturalis for treating and managing venous ulcers of the lower limb. This article will describe the composition of the ointment and its role in treating and managing venous ulcers.

CleaDerma DCB Ointment for the Treatment of Venous Ulcers

Pharma Naturalis formulate the CleaDerma DCB Ointment. This ointment has an all-natural active ingredients formula and is used for treating various skin conditions such as venous ulcers, pressure ulcers, xerosis, and diabetic ulcers. The special and unique formula enables the ointment to work on damaged skin tissues. The ingredients provide the skin with all the necessary building materials to regenerate, revive, and rejuvenate itself, which otherwise does not reach natural mechanisms. [3]

The healing properties of the CleaDerma DCB Ointment are attributed to its active ingredients – Dead Sea salt, calendula oil, aloe vera, sage, and avocado oil. These ingredients are enriched with all the micronutrients, macronutrients, and other substances required for the skin to revive, rejuvenate, heal, and regain its natural properties, such as elasticity. [3]

Benefits of Ingredients in the CleaDerma DCB Ointment

1. The venous ulcer wounds are vulnerable to bacterial, fungal, and viral infections, further damaging the tissues. The discharge from these ulcer wounds further deteriorates the appearance of the skin. Aloe vera has antimicrobial properties, particularly against multi-drug-resistant bacterial organisms. A study demonstrated the effectiveness of aloe vera dressing in reducing the bacterial load in venous ulcers and reduction in the size of the granulation tissue. The topical application of CleaDerma DCB with aloe vera also promotes wound healing by rapidly alleviating inflammation and discharge from venous ulcer wounds. The antimicrobial properties of aloe vera are attributed to anthraquinones and hormones. [4]
2. Delayed wound healing and superimposed microbial infections have detrimental effects. Anti-inflammatory processes on venous ulcer wounds originating from Calendula officinalis. The calendula oil has antibacterial and anti-inflammatory properties, promotes the healing of ulcers, and facilitates the epithelization of wounds. Triterpenes in calendula oil have anti-inflammatory properties. Triterpene faradiol palmitic ester is responsible for stimulating collagen production by the fibroblasts. Calendula oil, particularly flavonoids, also suppress the growth of microorganisms. [5]
3. Avocado oil has biologically active compounds, including tocopherols, lipidic furans, sterols, squalene, proteins, lecithin, potassium, fatty acids, beta-carotene, and vitamins A, D, C, and E. Avocado oil facilitates the contraction and epithelization of wounds. It also facilitates the production of collagen by fibroblasts in the granulation tissue. Increased concentration of monounsaturated fats in the avocado oil enables the ingredient to absorb into the skin. [6]
4. Sage (Salvia officinalis) has anti-inflammatory, antioxidant, and antibacterial properties, making it an effective ingredient for treating venous ulcers. Sage also demonstrates anti-exudative properties. [7]
5. Dead Sea salts exhibit healing properties for venous ulcers. Dead Sea salts accelerate wound healing and wound contraction. They enhance granulation, epithelization (due to the high concentration of magnesium), collagen production and deposition, and angiogenesis at the wound site. Dead Sea salts demonstrate anti-inflammatory, antioxidant, and antimicrobial properties, making these ingredients effective for healing venous ulcers. [8]

The healing properties of the CleaDerma DCB Ointment are attributed to its active ingredients – Dead Sea salt, calendula oil, aloe vera, sage, and avocado oil. These ingredients are enriched with all the micronutrients, macronutrients, and other substances required for the skin to regenerate, revive, rejuvenate, heal, and regain its natural properties, such as elasticity. [3]

Potential Adverse Effects of CleaDerma DCB Ointment

CleaDerma DCB Ointment topical application is safe for adults and children older than 3 years of age. Before using the ointment, one must go through the list of ingredients to check for ingredient(s) associated with prior allergies. 

Conclusion

CleaDerma DCB Ointment is a practical, cost-efficient, and all-natural active ingredients topical formulation for treating various skin conditions, including diabetic ulcers, xerosis, pressure ulcers, and venous ulcers. This ointment nourishes the skin with all the important ingredients required by the skin for its healing, revival, and rejuvenation.

The active ingredients include Dead Sea salts, avocado oil, calendula oil, sage, and aloe vera. These ingredients have anti-inflammatory, angiogenic, wound healing, antimicrobial, and antioxidant properties, which facilitate the treatment of venous ulcers. The cumulative action of these ingredients alleviates inflammation and restores the skin’s natural properties.

References

1. https://www.aafp.org/pubs/afp/issues/2019/0901/p298.html
2. https://www.ncbi.nlm.nih.gov/books/NBK567802/
3. https://dcb-care.com/case-study/
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395293/
5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270572/
6. https://www.researchgate.net/publication/5475316_Wound_healing_activity_of_Persea_americana_avocado_fruit_a_preclinical_study_on_rats
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950104/
8. https://scialert.net/fulltext/?doi=pjbs.2012.306.315