Introduction

Venous ulcers are described as open lesions that arise on the lower extremities. Approximately 1-3% of the total United States population suffers from venous ulcers. Venous ulcers arise in individuals who are suffering from venous hypertension. This condition may be a result of obstruction of the veins or incompetence of the valves leading to venous reflux. Important risk factors are positive family history of venous reflux or valve incompetence, a history of thrombus or embolus formation, 55 years of age or older, musculoskeletal disorder of the lower extremity, physical inactivity, multiple pregnancies, and severe lipo-dermatosclerosis.

While some lesions in venous ulcers heal, healing in other cases may be hindered by poor prognostic factors such as duration longer than three months, length of ulcers more than 10 cm, older age, increased body mass index, and pre-existing arterial disease of the lower limb. [1]

The standard therapeutic measures for treating and managing venous ulcers include compression therapy, which reduces leg edema, and direct management of the wound. In addition to non-invasive procedures, invasive interventions are required to remove incompetent veins. Techniques used for removing such veins include open vascular surgery, endovenous procedures, sclerotherapy, and radiofrequency. [2]

Venous ulcers can deteriorate the quality of life of an individual. From the non-satisfactory cosmetic appearance of the skin to bad odor and damaged tissues, venous ulcers can take a toll on one’s life. Although the above-mentioned treatments are efficacious, they are invasive and can be expensive. Not everyone is ready to be under the knife.

CleaDerma DCB Ointment is a cost-efficient, non-invasive, and effective topical formulation, developed by Pharma Naturalis, for the treatment and management of venous ulcers of the lower limb. This article will describe the composition of the ointment and its role in the treatment and management of venous ulcers.

CleaDerma DCB Ointment for the Treatment of Venous Ulcers

The CleaDerma DCB Ointment is formulated by Pharma Naturalis. This ointment has an all-natural active ingredients formula and is used for treating a variety of skin conditions such as venous ulcers, pressure ulcers, xerosis, and diabetic ulcers. The special and unique formula enables the ointment to work on damaged skin tissues. The ingredients provide the skin with all the necessary building materials to regenerate, revive, and rejuvenate itself, which otherwise do not reach by natural mechanisms. [3]

The healing properties of the CleaDerma DCB Ointment are attributed to its active ingredients – Dead Sea salt, calendula oil, aloe vera, sage, and avocado oil. These ingredients are enriched with all the micronutrients, macronutrients, and other substances required for the skin to revive, rejuvenate, heal, and regain its natural properties such as elasticity. [3]

Benefits of Ingredients in the CleaDerma DCB Ointment

1. The venous ulcer wounds are vulnerable to bacterial, fungal, and viral infections which further damage the tissues. The discharge from these ulcer wounds further deteriorates the appearance of the skin. Aloe vera has antimicrobial properties, particularly against multi-drug-resistant bacterial organisms. A study demonstrated the effectiveness of aloe vera dressing in reducing the bacterial load in venous ulcers and reduction in the size of the granulation tissue. The topical application of CleaDerma DCB with aloe vera also promotes wound healing by rapid alleviation of inflammation and discharge from venous ulcer wounds. The antimicrobial properties of aloe vera are attributed to anthraquinones and hormones. [4]
2. Delayed wound healing and superimposed microbial infections have detrimental effects. Anti-inflammatory processes on venous ulcer wounds originating from Calendula officinalis. The calendula oil has antibacterial and anti-inflammatory properties, promotes the healing of ulcers and facilitates the epithelization of wounds. Triterpenes in the calendula oil have anti-inflammatory properties. Triterpene faradiol palmitic ester is responsible for stimulating collagen production by the fibroblasts. Calendula oil, particularly flavonoids, also suppresses the growth of microorganisms. [5]
3. Avocado oil has biologically active compounds including tocopherols, lipidic furans, sterols, squalene, proteins, lecithin, potassium, fatty acids, beta-carotene, and vitamins A, D, C, and E. Avocado oil facilitates the contraction and epithelization of wounds. It also facilitates the production of collagen by fibroblasts in the granulation tissue. Increased concentration of monounsaturated fats in the avocado oil enables the ingredient to absorb into the skin. [6]
4. Sage (Salvia officinalis) has anti-inflammatory, antioxidant, and antibacterial properties, making it an effective ingredient for the treatment of venous ulcers. Sage also demonstrates anti-exudative properties. [7]
5. Dead Sea salts exhibit healing properties for venous ulcers. Dead Sea salts accelerate wound healing and wound contraction. They enhance granulation, epithelization (due to high concentration of magnesium), collagen production and deposition, and angiogenesis at the wound site. Dead Sea salts demonstrate anti-inflammatory, antioxidant, and antimicrobial properties, which make these ingredients effective for the healing of venous ulcers. [8]

The healing properties of the CleaDerma DCB Ointment are attributed to its active ingredients – Dead Sea salt, calendula oil, aloe vera, sage, and avocado oil. These ingredients are enriched with all the micronutrients, macronutrients, and other substances required for the skin to regenerate, revive, rejuvenate, heal, and regain its natural properties such as elasticity. [3]

Potential Adverse Effects of CleaDerma DCB Ointment

The topical application of CleaDerma DCB Ointment is safe for adults and children older than 3 years of age. Before using the ointment, one must go through the list of ingredients to check for ingredient(s) associated with prior allergies. 

Conclusion

CleaDerma DCB Ointment is an effective, cost-efficient, and all-natural active ingredients topical formulation for the treatment of a variety of skin conditions including diabetic ulcers, xerosis, pressure ulcers, and venous ulcers. This ointment nourishes the skin with all the important ingredients required by the skin for its healing, revival, and rejuvenation.

The active ingredients include Dead Sea salts, avocado oil, calendula oil, sage, and aloe vera. These ingredients have anti-inflammatory, angiogenic, wound healing, antimicrobial, and antioxidant properties, which facilitate the treatment of venous ulcers. The cumulative action of these ingredients alleviates inflammation and restores the natural properties of the skin.

References

1. https://www.aafp.org/pubs/afp/issues/2019/0901/p298.html
2. https://www.ncbi.nlm.nih.gov/books/NBK567802/
3. https://dcb-care.com/case-study/
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395293/
5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270572/
6. https://www.researchgate.net/publication/5475316_Wound_healing_activity_of_Persea_americana_avocado_fruit_a_preclinical_study_on_rats
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950104/
8. https://scialert.net/fulltext/?doi=pjbs.2012.306.315